Our research covers a broad range of topics unified by one theme: protein folding. Many human diseases result from defective protein folding, from Alzheimer’s and Parkinson’s diseases to many metabolic disorders.
Through biochemistry, biophysics and molecular biology approaches we investigate the mechanisms of protein folding and the consequences of protein misfolding, and how this impact on the cellular system. Specifically, we seek to elucidate molecular mechanisms in neurodegeneration and metabolic dysfunction.
Experimentally, we seek an integrated approach, from molecules to cells to organisms, to study pathomechanisms of diseases with a high societal impact, such as Alzheimer’s Disease. Our research laboratory is part of BioISI, Biosystems and Integrative Sciences Institute.